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KMID : 1149220070150010175
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Korean Journal of Oriental Medical Prescription
2007 Volume.15 No. 1 p.175 ~ p.183
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Anti-inflammatory Effect of Yongseollan on the LPS-activated RAW 264.7 Cells
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Jo Mi-Jeong
Lee Byung-Wook
Eom Dong-Myung
Lee Jong-Rok
Hwangbo Min
Jee Seon-Young
Kim Sang-Chan
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Abstract
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This study was conducted to evaluate the inhibitory effects of Yongseollan(YSL) on the production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 cells. YSL is tropical plant originating from Mexico. The biological activity of this plant is not yet evaluated systematically. The aim of the present work is to investigate a potential anti-inflammatory activity of YSL. The RAW264.7 cells were cultured in D MEM/F12 medium for 24 hrs. After serum starvation, cells were treated with YSL for 1 hr, followed by stimulating NO production with a LPS. We found that YSL has an inhibitory effect on the production of NO, iNOS expression and phospho-IκB expression. YSL also inhibited tumor necrosis factor TNF-α, interleukin (IL)-6, and IL-1β. Moreover, YSL inhibited cyclooxygenase (COX)-2 expression and prostanglandin E2 (PGE2). These findings showed that YSL could have some anti-inflammatory effects which might play a role in therapy in Gram-negative bacterial infections.
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KEYWORD
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Yongseollan(YSL), LPS, iNOS, COX-2
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